A Randomized Controlled Trial Comparing Efficacy of Pentoxifylline and Pioglitazone on Metabolic Factors and Liver Histology in Patients with Non-alcoholic Steatohepatitis.

@article{Sharma2012ARC,
  title={A Randomized Controlled Trial Comparing Efficacy of Pentoxifylline and Pioglitazone on Metabolic Factors and Liver Histology in Patients with Non-alcoholic Steatohepatitis.},
  author={Barjesh Chander Sharma and Ajay Kumar and Vishal Garg and Ravi Sankar Reddy and Puja Sakhuja and Shiv Kumar Sarin},
  journal={Journal of clinical and experimental hepatology},
  year={2012},
  volume={2 4},
  pages={333-7}
}
BACKGROUND AND AIMS Non-alcoholic steatohepatitis (NASH) involves increased hepatic macrosteatosis due to increased insulin resistance and non-hepatic processes including oxidative stress, apoptosis, and increased pro-inflammatory cytokines. Present study compared the efficacy of pentoxifylline and pioglitazone therapy in improving the metabolic factors and liver histology in patients with NASH. METHODS Sixty consecutive biopsy proven NASH patients aged 18-70 years with ALT > 1.2 times the… CONTINUE READING

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