A Randomized Clinical Trial of Daunorubicin and a Combination of Prednisone , Vincristine , 6-Mercaptopurine , and Methotrexate in Adult Acute Nonlymphocytic Leukemia 1

Abstract

Twenty-two adult patients with acute nonlymphocytic leukemia received daunorubicin, and 21 received a combina tion of prednisone, vincristine, 6-mercaptopurine, and methotrexate in a randomized study. The single agent was superior to the combination in inducing complete remission (50 versus 28%). In addition, patients who completely responded to… (More)

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