A Randomized, Prospective, Double‐Blind Study on the Efficacy of Dead Sea Salt Nasal Irrigations

  title={A Randomized, Prospective, Double‐Blind Study on the Efficacy of Dead Sea Salt Nasal Irrigations},
  author={Michael Friedman and Ramakrishnan Vidyasagar and Ninos J Joseph},
  journal={The Laryngoscope},
Objective: The objective of this randomized, prospective, double‐blind study was to compare nasal irrigation using hypertonic Dead Sea salt (DSS) solution with hypertonic saline in the treatment of chronic rhinosinusitis and improvement of quality of life (QOL). 

Dead Sea salt irrigations vs saline irrigations with nasal steroids for symptomatic treatment of chronic rhinosinusitis: a randomized, prospective double‐blind study

This study aimed to compare the efficacy of Dead Sea salt (DSS) irrigations and DSS nasal spray vs saline irrigation and topical nasal steroid spray in the treatment of symptoms of CRS.

Effect of Budesonide Added to Large-Volume, Low-pressure Saline Sinus Irrigation for Chronic Rhinosinusitis: A Randomized Clinical Trial

This study shows that budesonide in saline nasal lavage results in clinically meaningful benefits beyond the benefits of saline alone for patients with CRS, and given the imprecision in the treatment effect, further research is warranted.

The Potential Role of Hyaluronan in Minimizing Symptoms and Preventing Exacerbations of Chronic Rhinosinusitis

The results of this study suggested that intermittent treatment with topical 9-mg sodium hyaluronate plays a role in minimizing symptoms and could prevent exacerbations of CRS.

Comparison on the efficacy of dexpanthenol in sea water and saline in postoperative endoscopic sinus surgery.

The efficacy of dexpanthenol was comparable to nasal saline irrigation in the postoperative care of sinusitis patients following endoscopic sinus surgery and may be useful in young children and complicated cases.

Optimal Device and Regimen of Nasal Saline Treatment for Sinonasal Diseases: Systematic Review

Nasal saline treatment is recommended for treating most sinonasal diseases and Buffered isotonic saline was more tolerable than nonbuffered or hypertonic saline.

Nasal irrigation: From empiricism to evidence-based medicine. A review.

A two‐center, assessor‐blinded, prospective trial evaluating the efficacy of a novel hypertonic draining cream for cellulite reduction: A Clinical and instrumental (Antera 3D CS) assessment

A new hypertonic topical product with draining action (HTC) containing NaCl 13%, escine, caffeine, and beta‐sitosterol has been recently developed and a 28‐day double‐blind placebo‐controlled study has shown that this cream is able to reduce thigh circumference and the thickness of adipose tissue.

Commentary on ‘Nasal saline irrigations for the symptoms of chronic rhinosinusitis’

This is a commentary on a Cochrane review, published in this issue of EBCH, first published as: Nasal saline irrigations for the symptoms of chronic rhinosinusitis.



Clinical Study and Literature Review of Nasal Irrigation

The objective of this study was to determine the efficacy of the use of pulsatile hypertonic saline nasal irrigation in the treatment of sinonasal disease.

A Comparative Study of Three Methods of Nasal Irrigation

Objective: To assess the effectiveness of three methods of nasal irrigation on distributing saline to the nasal cavity and paranasal sinuses.

Efficacy of daily hypertonic saline nasal irrigation among patients with sinusitis: a randomized controlled trial.

Daily hypertonic saline nasal irrigation improves sinus-related quality of life, decreases symptoms, and decreases medication use in patients with frequent sinusitis and primary care physicians can feel comfortable recommending this therapy.

Bathing in a magnesium‐rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin

This work examined the efficacy of bathing atopic subjects in a salt rich in magnesium chloride from deep layers of the Dead Sea (Mavena® Dermaline Mg46 Dead Sea salt, Mavena AG, Belp, Switzerland).

Development and testing of a new measure of health status for clinical trials in rhinoconjunctivitis

  • E. JuniperG. Guyatt
  • Medicine
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
  • 1991
The RQLQ is likely to prove useful as a measure of health‐related quality of life in clinical trials in both rhinoconjunctivitis and rhinitis.

Evaluation of a multicentre study of synchronous application of narrowband ultraviolet B phototherapy (TL‐01) and bathing in Dead Sea salt solution for psoriasis vulgaris

A significant effect of therapy is demonstrated in both the ATP and the ITT groups for this new treatment system which imitates, as far as possible, the Dead Sea climatic conditions, with no severe side‐effects and a high acceptance by the patients.

Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis.

Inhalation of hypertonic saline is a potentially useful treatment in patients with cystic fibrosis as both the AML and HS solutions induced cough in some patients, and this was to eliminate the possible confounding effect of cough on MCC measurement.

Physiologic and hypertonic saline solutions impair ciliary activity in vitro.

The results of this study suggest that mucolytic effects induced by hyperosmolarity should be attained preferably with hypertonic saline 7% in patients with cystic fibrosis or asthma.

Inhalation of hypertonic saline aerosol enhances mucociliary clearance in asthmatic and healthy subjects.

It is concluded that an increase in osmolarity of the airway surface liquid increases mucociliary clearance both in asthmatic and healthy subjects, in keeping with the previous suggestion that the increase in mucOCiliary clearance after isotonic hyperventilation with dry air is due to a transient hyperosmolarity.