A Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome

@article{Kayumov2001ARD,
  title={A Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Effect of Exogenous Melatonin on Delayed Sleep Phase Syndrome},
  author={Leonid Kayumov and Gregory A. Brown and Ripu D. Jindal and Kenneth Buttoo and Colin Shapiro},
  journal={Psychosomatic Medicine},
  year={2001},
  volume={63},
  pages={40-48}
}
Objective The effects of exogenous melatonin on sleep, daytime sleepiness, fatigue, and alertness were investigated in 22 patients with delayed sleep phase syndrome whose nocturnal sleep was restricted to the interval from 24:00 to 08:00 hours. This study was a randomized, double-blind, placebo-controlled crossover trial. Subjects received either placebo or melatonin (5 mg) daily for 4 weeks, underwent a 1-week washout period, and then were given the other treatment for an additional 4 weeks… 
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References

SHOWING 1-10 OF 67 REFERENCES
Delayed sleep phase syndrome: A placebo‐controlled cross‐over study on the effects of melatonin administered five hours before the individual dim light melatonin onset
TLDR
The results show that analysis of DLMO of patients suffering from DSPS is important both for diagnosis and therapy, and actigraphy showed a significant advance of sleep onset and polysomnography, a significant decreased sleep latency.
Delayed sleep phase syndrome response to melatonin
Melatonin Administration to Blind People: Phase Advances and Entrainment
TLDR
The purpose of this study was to test the phase-shifting and entraining effects of melatonin in human subjects, and found five totally blind men found to have free-running endogenous melatonin rhythms to be remarkably stable.
Melatonin, and delayed sleep phase syndrome: ambulatory polygraphic evaluation
TLDR
Previous data obtained by a sleep-wake subjective diary on the efficacy of melatonin DSPS are confirmed, and mean advances in sleep onset time and in final awakening hour are confirmed.
Chronotherapy: resetting the circadian clocks of patients with delayed sleep phase insomnia.
TLDR
A brief drug-free rescheduling treatment for Delayed Sleep Phase insomnia, a syndrome characterized by sleep-onset insomnia with difficulty in morning awakening, which was designed to reset patients' biological clocks by the phase delay route.
REM sleep in depressed patients: different attempts to achieve adaptation.
Melatonin: Role in Gating Nocturnal Rise in Sleep Propensity
  • P. Lavie
  • Biology
    Journal of biological rhythms
  • 1997
TLDR
It is suggested that melatonin participates in the regulation of the sleep-wake cycle by inhibiting the central nervous system wakefulness generating system, which allows a smooth transition from wakefulness to sleep.
The delayed sleep phase syndrome: clinical and investigative findings in 14 subjects.
TLDR
The syndrome causes severe disruption to education, work and family life, and different patterns of sleep phase delay seen in the syndrome include stable, progressive, irregular and non-24 hour sleep-wake cycles.
Delayed sleep phase syndrome. A chronobiological disorder with sleep-onset insomnia.
TLDR
A new syndrome called "delayed sleep phase insomnia" is described, which is proposed to be a disorder of the circadian sleep-wake rhythm in which the "advance" portion of the phase response curve is small.
Melatonin in Psychiatric and Sleep Disorders
TLDR
Administration of melatonin or bright light treatment has established therapeutic actions in circadian rhythm sleep disorders, including disorders associated with jet lag, shift work, delayed phase sleep disorder, periodic sleep disorder in blindness, and sleep and behavioural disorders in children with multiple brain damage.
...
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