A Randomised, Double-Blind, Clinical Trial Comparing the Efficacy of Nimesulide, Celecoxib and Rofecoxib in Osteoarthritis of the Knee
@article{Bianchi2012ARD, title={A Randomised, Double-Blind, Clinical Trial Comparing the Efficacy of Nimesulide, Celecoxib and Rofecoxib in Osteoarthritis of the Knee}, author={Mauro Bianchi and M. Broggini}, journal={Drugs}, year={2012}, volume={63}, pages={37-46} }
AbstractJoint pain is the main complaint in patients affected by osteoarthritis (OA), and NSAIDs are commonly used to treat pain associated with OA. Over the past few years, cyclo-oxygenase (COX)-2-selective inhibitors have been proved to have certain advantages over non-selective NSAIDs and have been increasingly used for pain management in patients with OA.
Objective:The main objective of this randomised, double-blind, within-patient study was to compare the analgesic efficacy of three COX-2…
16 Citations
Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
- MedicineDrugs
- 2011
Celecoxib would appear to be a useful option for therapy in patients at high risk for NSAID-induced GI toxicity, or in those responding suboptimally to or intolerant of NSAIDs, as well as overviewing its pharmacological properties.
Celecoxib for osteoarthritis.
- MedicineThe Cochrane database of systematic reviews
- 2017
Celecoxib was compared with placebo, no intervention, placebo or another traditional NSAID (tNSAID) in participants with clinically- or radiologically-confirmed primary OA of the knee or hip, or both knee and hip and there was no evidence of an important difference for withdrawals due to adverse events.
Applying the Evidence in Osteoarthritis: Strategies for Pain Management
- MedicineClinical drug investigation
- 2007
Nimesulide is a NSAID with a multi-factorial mode of action which is particularly suitable in the symptomatic treatment of states characterised by acute pain, such as osteoarthritis flares, and data from several clinical studies suggest that NSAIDs provide superior analgesia to paracetamol.
Efficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms
- MedicineDrug design, development and therapy
- 2018
The present study demonstrated noninferiority of a 14-day regimen with a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for the treatment of osteoarticular pain.
Comparative efficacy of nimesulide and ketoprofen on inflammatory events in third molar surgery: a split-mouth, prospective, randomized, double-blind study.
- MedicineInternational journal of oral and maxillofacial surgery
- 2015
Acute pain: a multifaceted challenge – the role of nimesulide
- MedicineCurrent medical research and opinion
- 2016
Nimesulide, when used appropriately, remains a particularly valuable and safe option for the treatment of several conditions characterized by the presence of acute inflammatory pain because of the rapid onset of the analgesic action, and the positive evidence-based benefit/risk profile.
Effects of dexamethasone and nimesulide on bisphosphonate-related osteonecrosis of the jaw: An experimental study.
- MedicineArchives of oral biology
- 2017
Network Meta-Analysis Comparing Relatively Selective COX-2 Inhibitors Versus Coxibs for the Prevention of NSAID-Induced Gastrointestinal Injury
- MedicineMedicine
- 2015
Relatively selective COX-2 inhibitors appear to be associated with similar gastroprotective effect and tolerability as coxibs, and future research is required to confirm the study conclusion.
A qualitative study on patients with knee osteoarthritis to evaluate the influence of different pain patterns on patients’ quality of life and to find out patients’ interpretation and coping strategies for the disease
- Medicine
- 2011
The study findings can help healthcare providers to understand and be aware of the existence of two pain patterns, mechanical and inflammatory pain in knee OA, as well as to appreciate the great variations of symptoms, the different perspectives, and the different coping and health-seeking behaviors among knee Oa patients during their management.
Changes of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib
- Medicine
- 2019
Objectives: The aim of this Thesis was to conduct comprehensive analysis of
efficacy data for pain in randomized controlled trial RCTs about Celecoxi
References
SHOWING 1-10 OF 48 REFERENCES
Efficacy of rofecoxib, celecoxib, and acetaminophen in osteoarthritis of the knee: a randomized trial.
- MedicineJAMA
- 2002
A randomized, parallel-group, double-blind trial to assess the relative therapeutic efficacy of rofecoxib, celecoxib, and acetaminophen in adults with OA and more patients treated with acetaminphen discontinued early due to lack of efficacy than patients treating with COX-2 inhibitors.
Rofecoxib: a review of its use in the management of osteoarthritis, acute pain and rheumatoid arthritis.
- MedicineDrugs
- 2001
Rofecoxib provides an alternative treatment option to traditional NSAID therapy in the management of symptomatic pain relief in patients with osteoarthritis and is likely to become a valuable addition to current drug therapy for this patient population.
A randomized trial of the efficacy and tolerability of the COX-2 inhibitor rofecoxib vs ibuprofen in patients with osteoarthritis. Rofecoxib/Ibuprofen Comparator Study Group.
- MedicineArchives of internal medicine
- 2000
Rofecoxib was well tolerated and provided clinical efficacy comparable with a high dose of the NSAID ibuprofen in patients with OA.
Treatment of osteoarthritis with celecoxib, a cyclooxygenase-2 inhibitor: a randomized controlled trial.
- MedicineMayo Clinic proceedings
- 1999
COX-2 inhibition with celecoxib is an effective approach for the treatment of osteoarthritis, as seen by clinical improvement in signs and symptoms comparable to treatment with naproxen.
Celecoxib: a review of its use in osteoarthritis, rheumatoid arthritis and acute pain.
- MedicineDrugs
- 2000
Celecoxib is the first COX-2 specific inhibitor approved for use in osteoarthritis and rheumatoid arthritis and is associated with a lower incidence of upper gastrointestinal ulceration and complications.
Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: a randomized, double-blind, placebo-controlled trial. The Rofecoxib Osteoarthritis Endoscopy Multinational Study Group.
- MedicineArthritis and rheumatism
- 2000
At 2-4 times the therapeutically effective dose, rofecoxib caused fewer endoscopically detected ulcers than did ibuprofen.
Comparison of once-daily and twice-daily administration of celecoxib for the treatment of osteoarthritis of the knee.
- MedicineClinical therapeutics
- 2001
Double-blind, randomised, multi-centre clinical study evaluating the efficacy and tolerability of nimesulide in comparison with etodalac in patients suffering from osteoarthritis of the knee.
- MedicineEuropean journal of rheumatology and inflammation
- 1994
There was no difference in the rate of incidence of AEs and, with the exception of week 8 where etodolac was apparently better tolerated, there were no statistical differences in tolerability between the two therapies.
Nimesulide in the Treatment of Osteoarthritis
- MedicineDrugs
- 2012
In all studies, nimesulide improved the improvement in spontaneous pain and other efficacy parameters with an activity significantly superior to that of placebo and comparable with that of reference drugs.