A Randomised, Double-Blind, Clinical Trial Comparing the Efficacy of Nimesulide, Celecoxib and Rofecoxib in Osteoarthritis of the Knee

@article{Bianchi2012ARD,
  title={A Randomised, Double-Blind, Clinical Trial Comparing the Efficacy of Nimesulide, Celecoxib and Rofecoxib in Osteoarthritis of the Knee},
  author={Mauro Bianchi and M. Broggini},
  journal={Drugs},
  year={2012},
  volume={63},
  pages={37-46}
}
AbstractJoint pain is the main complaint in patients affected by osteoarthritis (OA), and NSAIDs are commonly used to treat pain associated with OA. Over the past few years, cyclo-oxygenase (COX)-2-selective inhibitors have been proved to have certain advantages over non-selective NSAIDs and have been increasingly used for pain management in patients with OA. Objective:The main objective of this randomised, double-blind, within-patient study was to compare the analgesic efficacy of three COX-2… 
Celecoxib: a review of its use for symptomatic relief in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.
TLDR
Celecoxib would appear to be a useful option for therapy in patients at high risk for NSAID-induced GI toxicity, or in those responding suboptimally to or intolerant of NSAIDs, as well as overviewing its pharmacological properties.
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TLDR
Celecoxib was compared with placebo, no intervention, placebo or another traditional NSAID (tNSAID) in participants with clinically- or radiologically-confirmed primary OA of the knee or hip, or both knee and hip and there was no evidence of an important difference for withdrawals due to adverse events.
Applying the Evidence in Osteoarthritis: Strategies for Pain Management
TLDR
Nimesulide is a NSAID with a multi-factorial mode of action which is particularly suitable in the symptomatic treatment of states characterised by acute pain, such as osteoarthritis flares, and data from several clinical studies suggest that NSAIDs provide superior analgesia to paracetamol.
Efficacy and safety of a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for pain relief in patients with osteoarticular diseases and dyspeptic symptoms
TLDR
The present study demonstrated noninferiority of a 14-day regimen with a fixed-dose combination of nimesulide/pantoprazole compared to naproxen/esomeprazole for the treatment of osteoarticular pain.
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TLDR
Nimesulide, when used appropriately, remains a particularly valuable and safe option for the treatment of several conditions characterized by the presence of acute inflammatory pain because of the rapid onset of the analgesic action, and the positive evidence-based benefit/risk profile.
Network Meta-Analysis Comparing Relatively Selective COX-2 Inhibitors Versus Coxibs for the Prevention of NSAID-Induced Gastrointestinal Injury
TLDR
Relatively selective COX-2 inhibitors appear to be associated with similar gastroprotective effect and tolerability as coxibs, and future research is required to confirm the study conclusion.
A qualitative study on patients with knee osteoarthritis to evaluate the influence of different pain patterns on patients’ quality of life and to find out patients’ interpretation and coping strategies for the disease
TLDR
The study findings can help healthcare providers to understand and be aware of the existence of two pain patterns, mechanical and inflammatory pain in knee OA, as well as to appreciate the great variations of symptoms, the different perspectives, and the different coping and health-seeking behaviors among knee Oa patients during their management.
Changes of pain intensity results with different follow-up times in randomized controlled trials of osteoarthritis : a case study of celecoxib
Objectives: The aim of this Thesis was to conduct comprehensive analysis of efficacy data for pain in randomized controlled trial RCTs about Celecoxi
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