A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

@article{Brennan2011ARA,
  title={A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK},
  author={Damian F. Brennan and Arvin C. Dar and Nicholas T Hertz and William Chong Hang Chao and Alma L. Burlingame and Kevan M. Shokat and David Barford},
  journal={Nature},
  year={2011},
  volume={472},
  pages={366-369}
}
In metazoans, the Ras–Raf–MEK (mitogen-activated protein-kinase kinase)–ERK (extracellular signal-regulated kinase) signalling pathway relays extracellular stimuli to elicit changes in cellular function and gene expression. Aberrant activation of this pathway through oncogenic mutations is responsible for a large proportion of human cancer. Kinase suppressor of Ras (KSR) functions as an essential scaffolding protein to coordinate the assembly of Raf–MEK–ERK complexes. Here we integrate… 

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...

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