A ROLE FOR 1,25-DIHYDROXYVITAMIN D3 IN CONTROL OF BONE-MARROW COLLAGEN DEPOSITION?

@article{McCarthy1984ARF,
  title={A ROLE FOR 1,25-DIHYDROXYVITAMIN D3 IN CONTROL OF BONE-MARROW COLLAGEN DEPOSITION?},
  author={D. McCarthy and J. Hibbin and J. Goldman},
  journal={The Lancet},
  year={1984},
  volume={323},
  pages={78-80}
}
It is suggested that 1,25-dihydroxyvitamin D3 (1,25-[OH]2D3), the active hormonal metabolite of vitamin D3, inhibits the formation of fibrous tissue (mainly collagen) in bone-marrow and also increases its degradation. 1,25-(OH)2D3 inhibits the proliferation of megakaryocytes which normally promote collagen synthesis. The hormone also directly antagonises collagen synthesis. Degradation of fibrous tissue is mediated by monocytes and macrophages, which contain collagenase, and the number and… Expand
Localized scleroderma—response to 1,25‐dihydroxyvitamin D3
Enhanced expression of urokinase activity on U 937 cell line by 1,25-dihydroxyvitamin D3 induction.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 17 REFERENCES
Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3.
1 alpha,25-Dihydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 prolong survival time of mice inoculated with myeloid leukemia cells.
  • Y. Honma, M. Hozumi, +6 authors T. Suda
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1983
Bone Metabolism and Calcium Regulation
Biochemical and Histological Analysis of Bone Marrow Collagen in Myelofibrosis
Growth inhibition of human breast cancer cells induced by calcitonin.
Myeloid metaplasia in vitamin D deficiency rickets.
Transitions in collagen types during matrix-induced cartilage, bone, and bone marrow formation.
...
1
2
...