A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines.

@article{Tsuji2000ARG,
  title={A REIC gene shows down-regulation in human immortalized cells and human tumor-derived cell lines.},
  author={Toshiya Tsuji and Masahiro Miyazaki and Masakiyo Sakaguchi and Yusuke Inoue and Masayoshi Namba},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={268 1},
  pages={
          20-4
        }
}
Normal human cells stop proliferation after a certain number of cell divisions. This phenomenon is called cellular aging. The fact that the senescence phenotype is dominant and the immortal one is recessive indicates that immortalization of human cells may be caused by loss of functions of certain genes in normal cells. Based on this evidence, several cDNA clones whose expression was down-regulated during the immortalization process of human cells were isolated by the representative difference… CONTINUE READING
BETA

Citations

Publications citing this paper.
SHOWING 1-10 OF 97 CITATIONS, ESTIMATED 48% COVERAGE

Function and biological roles of the Dickkopf family of Wnt modulators

  • Oncogene
  • 2006
VIEW 7 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

FILTER CITATIONS BY YEAR

2002
2019

CITATION STATISTICS

  • 5 Highly Influenced Citations

Similar Papers

Loading similar papers…