A Quiet Leader Unites Researchers in Drive for the Next Big Machine

  title={A Quiet Leader Unites Researchers in Drive for the Next Big Machine},
  author={Adrian Cho},
  pages={1128 - 1129}
  • A. Cho
  • Published 26 May 2006
  • Physics
  • Science
BATAVIA, ILLINOIS-- As head of the design team for the International Linear Collider, Barry Barish has physicists around the globe pulling together. But can the governments of the world afford their enormous particle smasher? (Read more.) 
5 Citations
Aryl Hydrocarbon Receptor–Interacting Protein (AIP) N-Terminus Gene Mutations Identified in Pituitary Adenoma Patients Alter Protein Stability and Function
Results indicate that N-terminus mutations lead to de-regulation of the effect of WT AIP on cAMP signalling and increased cAMP thresholds in GH3 cells resulting in increased growth hormone (GH) secretion.
cAMP signalling in the normal and tumorigenic pituitary gland
Aryl hydrocarbon receptor (AHR) is a potential tumour suppressor in pituitary adenomas
Functional studies support a mechanistic pathway for the putative tumour suppressive role of AHR specifically in PA, possibly through its role as a cell cycle co-regulator, even in the absence of exogenous ligands.
Aip regulates cAMP signalling and GH secretion in GH3 cells.
The functional role of AIP was investigated using both over-expression and knock down of Aip in GH3 cells and a mechanism by which Aip acts as a tumour suppressor, by maintaining a low cAMP signalling and concentration, is suggested.
Expression and Clinical Significance of Wnt Players and Survivin in Pituitary Tumours
The data suggest that c-MYC may have an important role in early pituitary tumorigenesis while Cyclin D1 is likely to promote tumour growth at a later stage, and a novel gender difference in CyclinD1 expression is reported, the biological significance of which merits further analysis.