A Quantitative Systems Pharmacology Perspective on Cancer Immunology

@inproceedings{ByrneHoffman2015AQS,
  title={A Quantitative Systems Pharmacology Perspective on Cancer Immunology},
  author={Christina N Byrne-Hoffman and David J. Klinke},
  year={2015}
}
The return on investment within the pharmaceutical industry has exhibited an exponential decline over the last several decades. Contemporary analysis suggests that the rate-limiting step associated with the drug discovery and development process is our limited understanding of the disease pathophysiology in humans that is targeted by a drug. Similar to other industries, mechanistic modeling and simulation has been proposed as an enabling quantitative tool to help address this problem. Moreover… CONTINUE READING