A Quantitative Model of Transcriptional Regulation Reveals the Influence of Binding Location on Expression

@inproceedings{MacIsaac2010AQM,
  title={A Quantitative Model of Transcriptional Regulation Reveals the Influence of Binding Location on Expression},
  author={Kenzie D. MacIsaac and Kinyui A. Lo and William Gordon and Shmulik Motola and Tali Mazor and Ernest Fraenkel},
  booktitle={PLoS Computational Biology},
  year={2010}
}
Understanding the mechanistic basis of transcriptional regulation has been a central focus of molecular biology since its inception. New high-throughput chromatin immunoprecipitation experiments have revealed that most regulatory proteins bind thousands of sites in mammalian genomes. However, the functional significance of these binding sites remains unclear. We present a quantitative model of transcriptional regulation that suggests the contribution of each binding site to tissue-specific gene… CONTINUE READING

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