A Quantitative Model for Ordered Cdk Substrate Dephosphorylation during Mitotic Exit

@article{Bouchoux2011AQM,
  title={A Quantitative Model for Ordered Cdk Substrate Dephosphorylation during Mitotic Exit},
  author={C{\'e}line Bouchoux and Frank Uhlmann},
  journal={Cell},
  year={2011},
  volume={147},
  pages={803-814}
}
After sister chromatid splitting at anaphase onset, exit from mitosis comprises an ordered series of events. Dephosphorylation of numerous mitotic substrates, which were phosphorylated by cyclin-dependent kinase (Cdk), is thought to bring about mitotic exit, but how temporal ordering of mitotic exit events is achieved is poorly understood. Here, we show, using budding yeast, that dephosphorylation of Cdk substrates involved in sequential mitotic exit events occurs with ordered timing. We test… CONTINUE READING
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