A Quantitative Correlation of the Effect of Density Distributions in Roller-Compacted Ribbons on the Mechanical Properties of Tablets Using Ultrasonics and X-ray Tomography

@article{Akseli2011AQC,
  title={A Quantitative Correlation of the Effect of Density Distributions in Roller-Compacted Ribbons on the Mechanical Properties of Tablets Using Ultrasonics and X-ray Tomography},
  author={Ilgaz Akseli and Srinivas Iyer and Hwahsiung P. Lee and Alberto M. Cuiti{\~n}o},
  journal={AAPS PharmSciTech},
  year={2011},
  volume={12},
  pages={834-853}
}
Enabling the paradigm of quality by design requires the ability to quantitatively correlate material properties and process variables to measureable product performance attributes. In this study, we show how heterogeneities in compacted ribbon densities quantitatively correlate to tablet mechanical properties. These density variations, which have been purposely modulated by internal and external lubrications, are characterized longitudinally and transversally by nondestructive ultrasonic and X… CONTINUE READING

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