A Quality Control Program within a Clinical Trial Consortium for PCR Protocols To Detect Plasmodium Species

  title={A Quality Control Program within a Clinical Trial Consortium for PCR Protocols To Detect Plasmodium Species},
  author={Steve M Taylor and A. Mayor and G. Mombo-Ngoma and Hilaire M Kenguele and S. Ou{\'e}draogo and N. Ndam and Happy Mkali and G. Mwangoka and N. Valecha and J. Singh and M. Clark and J. Verweij and A. Adegnika and C. Severini and M. Menegon and E. Macete and C. Men{\'e}ndez and P. Cisteró and F. Njie and M. Affara and K. Otieno and S. Kariuki and F. T. Ter Kuile and S. Meshnick},
  journal={Journal of Clinical Microbiology},
  pages={2144 - 2149}
ABSTRACT Malaria parasite infections that are only detectable by molecular methods are highly prevalent and represent a potential transmission reservoir. The methods used to detect these infections are not standardized, and their operating characteristics are often unknown. We designed a proficiency panel of Plasmodium spp. in order to compare the accuracy of parasite detection of molecular protocols used by labs in a clinical trial consortium. Ten dried blood spots (DBSs) were assembled that… Expand
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