A PvuII restriction fragment length polymorphism of the glucose-6-phosphate dehydrogenase gene is an African-specific marker

@article{Fey1990APR,
  title={A PvuII restriction fragment length polymorphism of the glucose-6-phosphate dehydrogenase gene is an African-specific marker},
  author={Martin F. Fey and Jim S Wainscoat and E. C. Mukwala and Adeyinka G. Falusi and Tom Vulliamy and Lucio Luzzatto},
  journal={Human Genetics},
  year={1990},
  volume={84},
  pages={471-472}
}
SummaryThe site of a PvuII restriction fragment length polymorphism (RFLP) of the human glucose-6-phosphate dehydrogenase (G6PD) gene has been located in intron V, 60 bp upstream of G6PD exon VI. A population survey shows this RFLP to be specific for African populations, with frequencies of the rarer allele (PvuII type 2 site present) of 0.32–0.40 in Kenyans, Nigerians, Zambians, and West Indians. This allele has not been found in the European, Asian and Middle Eastern populations studied. Such… CONTINUE READING

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