A Putative Cyclic Nucleotide–Gated Channel Is Required for Sensory Development and Function in C. elegans

@article{Coburn1996APC,
  title={A Putative Cyclic Nucleotide–Gated Channel Is Required for Sensory Development and Function in C. elegans},
  author={Cara M. Coburn and Cornelia I Bargmann},
  journal={Neuron},
  year={1996},
  volume={17},
  pages={695-706}
}
In vertebrate visual and olfactory systems, a cyclic nucleotide-gated channel couples receptor activation to electrical activity of the sensory neurons. The Caenorhabditis elegans tax-2 gene is required for some forms of olfaction, for chemosensation of salts, and for thermosensation. We show here that tax-2 encodes a predicted subunit of a cyclic nucleotide-gated channel that is expressed in olfactory, gustatory, and thermosensory neurons, implicating this channel in multiple sensory… CONTINUE READING
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Mentioned Connections BETA
AxonNo subtypeCilia
Consistent with this proposed dual function , a Tax-2::GFP fusion protein is present both in sensory cilia and in sensory axons .
CiliaNo subtypeAxon
Consistent with this proposed dual function , a Tax-2::GFP fusion protein is present both in sensory cilia and in sensory axons .
Some sensory neurons display axon outgrowth defects in tax-2 mutants .
Some sensory neurons display axon outgrowth defects in tax-2 mutants .
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