A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

@article{Frster1996APC,
  title={A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen},
  author={Reinhold F{\"o}rster and A E Mattis and Elisabeth Kremmer and Eckhard Wolf and Gottfried Brem and Martin Lipp},
  journal={Cell},
  year={1996},
  volume={87},
  pages={1037-1047}
}
We describe the phenotype of gene-targeted mice lacking the putative chemokine receptor BLR1. In normal mice, this receptor is expressed on mature B cells and a subpopulation of T helper cells. Blr1 mutant mice lack inguinal lymph nodes and possess no or only a few phenotypically abnormal Peyer's patches. The migration of lymphocytes into splenic follicles is severely impaired, resulting in morphologically altered primary lymphoid follicles. Furthermore, activated B cells fail to migrate from… Expand
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References

SHOWING 1-10 OF 78 REFERENCES
The G protein‐coupled receptor BLR1 is involved in murine B cell differentiation and is also expressed in neuronal tissues
TLDR
The analysis of murine lymphoid tumor cell lines representing distinct stages of the B cell lineage reveals elevated expression of blr1 in B cell lymphomas but not in pre‐B lymphomas or plasmacytomas, suggesting that murine BLR1 may represent a cytokine/neuropeptide receptor exerting regulatory functions on recirculating mature B lymphocytes. Expand
Expression of the G-protein--coupled receptor BLR1 defines mature, recirculating B cells and a subset of T-helper memory cells
TLDR
Using a high-affinity anti-BLR1 monoclonal antibody (MoAb) and three-color flow cytometry, data suggest that the G-protein-coupled receptor BLR1 is involved in functional control of mature recirculating B cells and T- helper memory cells participating in cell migration and cell activation. Expand
Neutrophil and B cell expansion in mice that lack the murine IL-8 receptor homolog.
TLDR
This receptor was the major mediator of neutrophil migration to sites of inflammation and may provide a potential therapeutic target in inflammatory disease. Expand
Expression of the chemokine receptor BLR2/EBI1 is specifically transactivated by Epstein-Barr virus nuclear antigen 2.
TLDR
It is shown that transcription of the BLR2 gene could be specifically induced in Epstein-Barr virus negative BL 41 cells via estrogen-mediated activation of Epstein-barr virus nuclear antigen 2, a key regulator of viral and cellular genes in immortalized B cells. Expand
Recruitment of virgin B cells into an immune response is restricted to activation outside lymphoid follicles.
  • D. Gray
  • Biology, Medicine
  • Immunology
  • 1988
TLDR
The evidence presented suggests that activation of virgin B cells at extrafollicular sites in the spleen is required for both their incorporation into immune responses and into the recirculating pool. Expand
Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords
TLDR
Findings implicate a G protein-coupled receptor in lymphocyte migration into splenic white pulp cords and raises the possibility that the association observed between PTX treatment and predisposition to autoimmune disease results from inhibition of tolerance mechanisms that normally operate within secondary lymphoid tissues. Expand
Mice deficient for the CD40 ligand.
TLDR
The study confirms the important role of CD40-CD40L interactions in thymus-dependent humoral immune responses and germinal center formation and indicates an inability to develop memory B cell responses. Expand
Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110.
TLDR
Activated human B cells and B cell lines were found to selectively adhere to germinal centers and the VLA-4 molecule on the lymphocyte and the adhesion molecule INCAM-110, expressed on follicular dendritic cells, supported this interaction. Expand
Differentiation‐specific expression of a novel G protein‐coupled receptor from Burkitt's lymphoma
TLDR
It is concluded that BLR1 may represent a potential candidate involved in the process of physiologic trafficking, cell‐cell interactions, and activation of mature B lymphocytes in lymphatic tissues and supports the hypothesis thatBLR1 exerts a regulatory function in BL lymphomagenesis and/or B cell differentiation. Expand
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation.
TLDR
It is suggested that CD40 is essential for T cell-dependent immunoglobulin class switching and germinal center formation, but not for in vivo Tcell-dependent IgM responses and T cell -independent antibody responses. Expand
...
1
2
3
4
5
...