A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense.

@article{Caughey2006APP,
  title={A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense.},
  author={George H. Caughey},
  journal={Current respiratory medicine reviews},
  year={2006},
  volume={2 39},
  pages={
          263-277
        }
}
Airways are protected from pathogens by forces allied with innate and adaptive immunity. Recent investigations establish critical defensive roles for leukocyte and mast cell serine-class peptidases garrisoned in membrane-bound organelles-here termed Granule-Associated Serine Peptidases of Immune Defense, or GASPIDs. Some better characterized GASPIDs include neutrophil elastase and cathepsin G (which defend against bacteria), proteinase-3 (targeted by antineutrophil antibodies in Wegener's… CONTINUE READING

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