A Public Database of Memory and Naive B-Cell Receptor Sequences

@inproceedings{DeWitt2016APD,
  title={A Public Database of Memory and Naive B-Cell Receptor Sequences},
  author={William S DeWitt and Paul Lindau and Thomas M. Snyder and Anna M. Sherwood and Marissa Vignali and Christopher S Carlson and Philip D. Greenberg and Natalie Duerkopp and Ryan Emerson and Harlan S. Robins},
  booktitle={PloS one},
  year={2016}
}
  • William S DeWitt, Paul Lindau, +7 authors Harlan S. Robins
  • Published in PloS one 2016
  • Biology, Medicine
  • The vast diversity of B-cell receptors (BCR) and secreted antibodies enables the recognition of, and response to, a wide range of epitopes, but this diversity has also limited our understanding of humoral immunity. We present a public database of more than 37 million unique BCR sequences from three healthy adult donors that is many fold deeper than any existing resource, together with a set of online tools designed to facilitate the visualization and analysis of the annotated data. We estimate… CONTINUE READING

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