A Protein-Phenotype Mutual Information Based Identification of Human Disease Genes

@article{Huang2009APM,
  title={A Protein-Phenotype Mutual Information Based Identification of Human Disease Genes},
  author={Junheng Huang and Yu Du and Guangri Quan and Dongjie Zhu},
  journal={2009 International Conference on Computational Intelligence and Software Engineering},
  year={2009},
  pages={1-4}
}
On the basis of the assumption that diseases with similar phenotypes are caused by functionally related genes, We describe a candidate gene prioritization method that is entirely based on mutual information of human protein–protein interactions and disease phenotypic similarities, and develop a tool named GENEDIG to calculate the mutual information concordance score between the human protein network and the phenotype network. This method is applicable to genetically uncharacterized phenotypes… CONTINUE READING

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