A Protein Complex Network of Drosophila melanogaster

  title={A Protein Complex Network of Drosophila melanogaster},
  author={K. G. Guruharsha and Jean-François Rual and Bo Zhai and Julian Mintseris and Pujita Vaidya and Namita Vaidya and Chapman Beekman and Christina Wong and David Y Rhee and Odise Cenaj and Emily McKillip and Saumini Shah and M. L. Stapleton and Kenneth H. Wan and Charles Yu and Bayan Parsa and Joseph W. Carlson and Xiao Chen and Bhaveen H. Kapadia and Krishnaswamy VijayRaghavan and Steven P Gygi and Susan E. Celniker and Robert A. Obar and S. Artavanis-Tsakonas},
Determining the composition of protein complexes is an essential step toward understanding the cell as an integrated system. Using coaffinity purification coupled to mass spectrometry analysis, we examined protein associations involving nearly 5,000 individual, FLAG-HA epitope-tagged Drosophila proteins. Stringent analysis of these data, based on a… CONTINUE READING