A Protective and Safe Intranasal RSV Vaccine Based on a Recombinant Prefusion-Like Form of the F Protein Bound to Bacterium-Like Particles

@inproceedings{Rigter2013APA,
  title={A Protective and Safe Intranasal RSV Vaccine Based on a Recombinant Prefusion-Like Form of the F Protein Bound to Bacterium-Like Particles},
  author={Alan Rigter and Ivy Widjaja and Hanneke Versantvoort and Frank E J Coenjaerts and Maarten L. van Roosmalen and Kees J. Leenhouts and Peter J. M. Rottier and Bert Jan Haijema and Cornelis A M de Haan},
  booktitle={PloS one},
  year={2013}
}
Respiratory syncytial virus (RSV) is an important cause of respiratory tract disease in infants and the elderly. Currently, no licensed vaccine against RSV is available. Here we describe the development of a safe and effective intranasal subunit vaccine that is based on recombinant fusion (F) protein bound to the surface of immunostimulatory bacterium-like particles (BLPs) derived from the food-grade bacterium Lactococcus lactis. Different variants of F were analyzed with respect to their… CONTINUE READING
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