A Prospective Study to Monitor for Tuberculosis During Anti-tumour Necrosis Factor Therapy in Patients With Inflammatory Bowel Disease and Immune-mediated Inflammatory Diseases
@article{Lee2018APS, title={A Prospective Study to Monitor for Tuberculosis During Anti-tumour Necrosis Factor Therapy in Patients With Inflammatory Bowel Disease and Immune-mediated Inflammatory Diseases}, author={Choon Kin Lee and Sunny Hei Wong and Grace Chung Yan Lui and Whitney Tang and Lai S Tam and Margaret Ip and Esther Hiu Yee Hung and Minhu Chen and Justin C.Y. Wu and Siew Chien Ng}, journal={Journal of Crohn's and Colitis}, year={2018}, volume={12}, pages={954–962} }
Background
Biologic therapies have revolutionised the treatment of immune-mediated diseases including inflammatory bowel disease [IBD] and rheumatological disorders. However, biologic treatments are associated with an increased risk of reactivation of latent tuberculosis. Data from regular monitoring for latent tuberculosis infection [LTBI] during biologic treatment are lacking.
Methods
Consecutive patients eligible for biologic therapies were screened for LTBI and prospectively followed up…
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