A Prospective Study of W-Acetyltransferase Genotype , Red Meat Intake , and Risk of Colorectal Cancer 1

  title={A Prospective Study of W-Acetyltransferase Genotype , Red Meat Intake , and Risk of Colorectal Cancer 1},
  author={Jia Chen and Meir Jonathan Stampfer and Heather and Larry Hough and Montserrat and Garcia-Closas and Walter and Christopher G Willett and M. Charles and H. Hennekens and Karl T. Kelsey and David J. Hunter},
Carcinogenic heterocyclic amines are activated by A'-acetyltransferase (NAT) enzymes, encoded by NATI and NAT2, to genotoxic compounds that can form DNA adducts in the colon epithelium. We have examined the relation of polymorphisms in the genes coding for both enzymes to risk of colorectal cancer and the gene-environment interaction with red meat intake among participants in the prospective Physicians' Health Study. Baseline blood samples from 212 men subsequently diagnosed with colo rectal… CONTINUE READING
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