A Proof-of-Principle Clinical Trial of Bexarotene in Patients with Non–Small Cell Lung Cancer

  title={A Proof-of-Principle Clinical Trial of Bexarotene in Patients with Non–Small Cell Lung Cancer},
  author={Konstantin H. Dragnev and W. Jeffrey Petty and Sumit J. Shah and Lionel D. Lewis and Candice C Black and Vincent A. Memoli and William C. Nugent and Thomas W. Hermann and Andrés Negro-Vilar and James R Rigas and Ethan Dmitrovsky},
  journal={Clinical Cancer Research},
  pages={1794 - 1800}
Purpose: Bexarotene is a rexinoid (selective retinoid X receptor agonist) that affects proliferation, differentiation, and apoptosis in preclinical studies. The relationship between bexarotene levels and biomarker changes in tumor tissues has not been previously studied. Experimental Design: BEAS-2B human bronchial epithelial (HBE) cells, retinoid-resistant BEAS-2B-R1 cells, A427, H226, and H358 lung cancer cells were treated with bexarotene. Proliferation and biomarker expression were assessed… 

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