A Promoter Polymorphism in the CD59 Complement Regulatory Protein Gene in Donor Lungs Correlates With a Higher Risk for Chronic Rejection After Lung Transplantation.

@article{Budding2016APP,
  title={A Promoter Polymorphism in the CD59 Complement Regulatory Protein Gene in Donor Lungs Correlates With a Higher Risk for Chronic Rejection After Lung Transplantation.},
  author={Kevin Budding and Ed A van de Graaf and Tineke Kardol-Hoefnagel and Jasper C. A. Broen and Johanna M Kwakkel-van Erp and E J D Oudijk and D. A. van Kessel and Cornelis Erik Hack and H G Otten},
  journal={American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons},
  year={2016},
  volume={16 3},
  pages={987-98}
}
Complement activation leads primarily to membrane attack complex formation and subsequent target cell lysis. Protection against self-damage is regulated by complement regulatory proteins, including CD46, CD55, and CD59. Within their promoter regions, single-nucleotide polymorphisms (SNPs) are present that could influence transcription. We analyzed these SNPs and investigated their influence on protein expression levels. A single SNP configuration in the promoter region of CD59 was found… CONTINUE READING
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