A Prolyl-Isomerase Mediates Dopamine-Dependent Plasticity and Cocaine Motor Sensitization

  title={A Prolyl-Isomerase Mediates Dopamine-Dependent Plasticity and Cocaine Motor Sensitization},
  author={Joo Min Park and Jia-hua Hu and Aleksandr Milshteyn and P Zhang and Chester G. Moore and Sungjin Park and Michael Datko and Racquel D. Domingo and Cindy M. Reyes and Xiaodong J. Wang and Felicia A. Etzkorn and Bo Xiao and K K Szumlinski and Dorothee Kern and David E. J. Linden and Paul F Worley},
Synaptic plasticity induced by cocaine and other drugs underlies addiction. Here we elucidate molecular events at synapses that cause this plasticity and the resulting behavioral response to cocaine in mice. In response to D1-dopamine-receptor signaling that is induced by drug administration, the glutamate-receptor protein metabotropic glutamate receptor 5 (mGluR5) is phosphorylated by microtubule-associated protein kinase (MAPK), which we show potentiates Pin1-mediated prolyl-isomerization of… CONTINUE READING
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