A Progesterone-CXCR4 Axis Controls Mammary Progenitor Cell Fate in the Adult Gland

Abstract

Progesterone drives mammary stem and progenitor cell dynamics through paracrine mechanisms that are currently not well understood. Here, we demonstrate that CXCR4, the receptor for stromal-derived factor 1 (SDF-1; CXC12), is a crucial instructor of hormone-induced mammary stem and progenitor cell function. Progesterone elicits specific changes in the… (More)
DOI: 10.1016/j.stemcr.2015.01.011

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