A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets.

@article{Scoville2016APC,
  title={A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets.},
  author={Steven D. Scoville and Bethany L. Mundy-Bosse and Michael H. Zhang and Li Chen and Xiaoli Zhang and Karen A. Keller and Tiffany Hughes and Luxi Chen and Stephanie Cheng and Stephen M Bergin and Hsiaoyin Charlene Mao and Susan McClory and Jianhua Yu and William E Carson and Michael A. Caligiuri and Aharon G. Freud},
  journal={Immunity},
  year={2016},
  volume={44 5},
  pages={1140-50}
}
The current model of murine innate lymphoid cell (ILC) development holds that mouse ILCs are derived downstream of the common lymphoid progenitor through lineage-restricted progenitors. However, corresponding lineage-restricted progenitors in humans have yet to be discovered. Here we identified a progenitor population in human secondary lymphoid tissues (SLTs) that expressed the transcription factor RORγt and was unique in its ability to generate all known ILC subsets, including natural killer… CONTINUE READING
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