A Probabilistic Methodology for Integrating Knowledge and Experiments on Biological Networks

@article{GatViks2006APM,
  title={A Probabilistic Methodology for Integrating Knowledge and Experiments on Biological Networks},
  author={Irit Gat-Viks and Amos Tanay and Daniela Raijman and Ron Shamir},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  year={2006},
  volume={13 2},
  pages={
          165-81
        }
}
Biological systems are traditionally studied by focusing on a specific subsystem, building an intuitive model for it, and refining the model using results from carefully designed experiments. Modern experimental techniques provide massive data on the global behavior of biological systems, and systematically using these large datasets for refining existing knowledge is a major challenge. Here we introduce an extended computational framework that combines formalization of existing qualitative… CONTINUE READING

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