A Probabilistic Graphical Model for Ab Initio Folding

@article{Zhao2009APG,
  title={A Probabilistic Graphical Model for Ab Initio Folding},
  author={Feng Zhao and Jian Peng and Joe DeBartolo and Karl F. Freed and Tobin R. Sosnick and Jinbo Xu},
  journal={Research in computational molecular biology : ... Annual International Conference, RECOMB ... : proceedings. RECOMB},
  year={2009},
  volume={5541},
  pages={59-73}
}
Despite significant progress in recent years, ab initio folding is still one of the most challenging problems in structural biology. This paper presents a probabilistic graphical model for ab initio folding, which employs Conditional Random Fields (CRFs) and directional statistics to model the relationship between the primary sequence of a protein and its… CONTINUE READING