A Primitive Growth Factor, NME7AB, Is Sufficient to Induce Stable Naïve State Human Pluripotency; Reprogramming in This Novel Growth Factor Confers Superior Differentiation

@article{Carter2016APG,
  title={A Primitive Growth Factor, NME7AB, Is Sufficient to Induce Stable Na{\"i}ve State Human Pluripotency; Reprogramming in This Novel Growth Factor Confers Superior Differentiation},
  author={M. G. Carter and B. Smagghe and A. K. Stewart and J. Rapley and E. Lynch and K. Bernier and K. W. Keating and V. M. Hatziioannou and E. J. Hartman and C. Bamdad},
  journal={STEM CELLS},
  year={2016},
  volume={34}
}
Scientists have generated human stem cells that in some respects mimic mouse naïve cells, but their dependence on the addition of several extrinsic agents, and their propensity to develop abnormal karyotype calls into question their resemblance to a naturally occurring “naïve” state in humans. Here, we report that a recombinant, truncated human NME7, referred to as NME7AB here, induces a stable naïve‐like state in human embryonic stem cells and induced pluripotent stem cells without the use of… Expand
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  • C. Ware
  • Biology, Medicine
  • Stem cells
  • 2017
Energy Metabolism Regulates Stem Cell Pluripotency
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