A Primer in Longitudinal Data Analysis

@article{Fitzmaurice2008API,
  title={A Primer in Longitudinal Data Analysis},
  author={Garrett M. Fitzmaurice and Caitlin Ravichandran},
  journal={Circulation},
  year={2008},
  volume={118},
  pages={2005-2010}
}
Longitudinal data, comprising repeated measurements of the same individuals over time, arise frequently in cardiology and the biomedical sciences in general. For example, Frison and Pocock1 used repeated measurements of the liver enzyme creatine kinase in serum of cardiac patients to study changes in liver function over a 12-month study period. The main goal, indeed the raison d’etre , of a longitudinal study is characterization of changes in the response of interest over time. Ordinarily… 

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