A Primary Microcephaly Protein Complex forms a ring around parental centrioles

@inproceedings{Sir2011APM,
  title={A Primary Microcephaly Protein Complex forms a ring around parental centrioles},
  author={Joo-Hee Sir and Alexis R. Barr and A Kefalides Nicholas and Of{\'e}lia P Carvalho and Maryam Khurshid and Alex J Sossick and Stefanie Reichelt and Clive S. D’Santos and C Geoffrey Woods and Fanni Gergely},
  booktitle={Nature Genetics},
  year={2011}
}
Autosomal recessive primary microcephaly (MCPH) is characterized by a substantial reduction in prenatal human brain growth without alteration of the cerebral architecture and is caused by biallelic mutations in genes coding for a subset of centrosomal proteins. Although at least three of these proteins have been implicated in centrosome duplication, the nature of the centrosome dysfunction that underlies the neurodevelopmental defect in MCPH is unclear. Here we report a homozygous MCPH-causing… CONTINUE READING
BETA

Figures and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 99 CITATIONS

FILTER CITATIONS BY YEAR

2012
2018

CITATION STATISTICS

  • 14 Highly Influenced Citations

  • Averaged 11 Citations per year over the last 3 years

References

Publications referenced by this paper.
SHOWING 1-10 OF 57 REFERENCES

implications for regulation of mitotic entry, centrosome amplification, and genome maintenance

  • Löffler, H. et al. Cep63 recruits Cdk1 to the centrosome
  • Cancer Res. 71, –2139
  • 2011

Similar Papers

Loading similar papers…