A Prevalent Cancer Associated Glycan , Globo H Ceramide , Induces Immunosuppression by Reducing Notch 1 Signaling

Globo H, a hexasaccharide (Fucα1→2Galβ1→3GalNAcβ1→3Galα1 →4Galβ1→ 4Glcβ1) was first identified as a ceramide linked glycolipid in human breast cancer cell line MCF-7 [1]. It has been reported to be expressed on a variety of cancers including breast, colon, ovarian, gastric, pancreatic, lung, and prostate cancers [2,3]. It was also found on breast cancer… CONTINUE READING

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