A Preliminary Study of Cocaine Absorption From the Nasal Mucosa

@article{Liao1999APS,
  title={A Preliminary Study of Cocaine Absorption From the Nasal Mucosa},
  author={B. S. Liao and R. Hilsinger and B. Rasgon and K. Matsuoka and K. Adour},
  journal={The Laryngoscope},
  year={1999},
  volume={109}
}
Objective/Hypothesis: To determine factors affecting the safe use of topical cocaine for anesthesia and vasoconstriction during rhinologic surgery. Study Design: Prospective, randomized study of the kinetics of cocaine absorption through human nasal mucosa in 12 consecutive patients without nasal mucosal disease who were having septoplasty or septorhinoplasty. Methods: With patients under general anesthesia, cocaine was applied topically to each nasal cavity by using cottonoid pledgets. Group I… Expand
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