A Preliminary Report on the Pharmacokinetics of Ofloxacin, Desmethyl Ofloxacin and Ofloxacin N-Oxide in Patients with Chronic Renal Failure

@article{White1987APR,
  title={A Preliminary Report on the Pharmacokinetics of Ofloxacin, Desmethyl Ofloxacin and Ofloxacin N-Oxide in Patients with Chronic Renal Failure},
  author={Dr L. O. White and Alasdair P Macgowan and Andrew M. Lovering and David S. Reeves and Ian G. Mackay},
  journal={Drugs},
  year={1987},
  volume={34},
  pages={56-61}
}
The in vitro activities of ofloxacin, desmethyl ofloxacin and ofloxacin N-oxide were determined and a specific high performance liquid chromatography (HPLC) assay for these 3 compounds was devised as part of a study of the pharmacokinetics of ofloxacin and its metabolites in patients with impaired renal function. Desmethyl ofloxacin had significant antimicrobial activity but less than that of the parent drug. In 2 patients with chronic renal failure, specific HPLC assay indicated an extended… CONTINUE READING

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