A Preliminary Genome-Wide Association Study of Acute Mountain Sickness Susceptibility in a Group of Nepalese Pilgrims Ascending to 4380 m.

@article{MacInnis2015APG,
  title={A Preliminary Genome-Wide Association Study of Acute Mountain Sickness Susceptibility in a Group of Nepalese Pilgrims Ascending to 4380 m.},
  author={Martin J. MacInnis and Nadia Widmer and Utsav Timulsina and Ankita Subedi and Ashmita Siwakoti and Bidur Prasad Pandit and Michael G. Freeman and Eric A Carter and Irina Manokhina and Ghan Bahadur Thapa and Michael Stephen Koehle},
  journal={High altitude medicine \& biology},
  year={2015},
  volume={16 4},
  pages={
          290-7
        }
}
There is significant interindividual variation in acute mountain sickness (AMS) susceptibility in humans. To identify genes related to AMS susceptibility, we used a genome-wide association study (GWAS) to simultaneously test associations between genetic variants dispersed throughout the genome and the presence and severity of AMS. DNA samples were collected from subjects who ascended rapidly to Gosainkunda, Nepal (4380 m), as part of the 2005, 2010, and 2012 Janai Purnima festivals. The Lake… 
EPAS1 and VEGFA gene variants are related to the symptoms of acute mountain sickness in Chinese Han population: a cross-sectional study
TLDR
Under the latest LLSS, it is found that EPAS1 and VEGFA gene variants are related to AMS susceptibility through different AMS-related symptoms in the Chinese Han population; this tool might be useful for screening susceptible populations and predicting clinical symptoms leading toAMS before an individual reaches HA.
The relationship between anxiety and acute mountain sickness
TLDR
Trait anxiety at low altitude was an independent predictor of future severe AMS development at HA and state anxiety at HA independently predicted AMS and its severity.
Acute high-altitude illness.
Letter by Basnyat on article by Hofmeyr et al. (Hofmeyr R, Tölken G, De Decker R. Acute high-altitude illness. S Afr J Med 2017;107(7):556-561. https://doi.org/10.7196/SAMJ.2017.v107i7.12612); and