A Predator Unmasked: Life Cycle of Bdellovibrio bacteriovorus from a Genomic Perspective

  title={A Predator Unmasked: Life Cycle of Bdellovibrio bacteriovorus from a Genomic Perspective},
  author={Snjezana Rendulic and Pratik D. Jagtap and Andrea Rosinus and Mark Eppinger and Claudia Baar and Christa Lanz and Heike Keller and Carey Lambert and Katy J. Evans and Alexander Goesmann and Folker Meyer and R. Elizabeth Sockett and Stephan C. Schuster},
  pages={689 - 692}
Predatory bacteria remain molecularly enigmatic, despite their presence in many microbial communities. Here we report the complete genome of Bdellovibrio bacteriovorus HD100, a predatory Gram-negative bacterium that invades and consumes other Gram-negative bacteria. Its surprisingly large genome shows no evidence of recent gene transfer from its prey. A plethora of paralogous gene families coding for enzymes, such as hydrolases and transporters, are used throughout the life cycle of B… 
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With the complete genome sequence for one Bdellovibrio strain now available, researchers now have an opportunity to evaluate the therapeutic potential of these predatory bacteria.
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Advances in understanding the basic biology and regulation of predation processes are paving the way for future potential therapeutic and bioremediation applications of this unusual bacterium.
Predatory mechanisms of Bdellovibrio and like organisms.
The idea of using predatory bacteria as therapeutic agents to combat pathogenic Gram-negative bacteria is intriguing, as they can prey upon human pathogenic bacteria including Salmonella, Pseudomonas and Escherichia coli.
Laboratory Maintenance of Bdellovibrio
The protocols described in this unit deal with the techniques required to grow this bacterium on its prey cells and novel protocols to evaluate Bdellovibrio predation.
Identification of Bdellovibrio bacteriovorus HD100 Bd0714 as a Nudix dGTPase
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Draft genome sequences for the obligate bacterial predators Bacteriovorax spp. of four phylogenetic clusters
The genomes from non-type strains isolated from aquatic environments are reported and the genomic features of the four strains are described and compared, together with the classification and annotation.
Predatory lifestyle of Bdellovibrio bacteriovorus.
  • R. Sockett
  • Biology
    Annual review of microbiology
  • 2009
This review considers what is known postgenomically about Bdellovibrio and its predatory lifestyle, drawing also from what was learned by the excellent microbial physiology work of the early BdllovIBrio researchers.


Morphological and physiological aspects of the interaction of Bdellovibrio with host bacteria.
  • M. Shilo
  • Environmental Science
    Current topics in microbiology and immunology
  • 1969
The discovery, several years ago, of Bdellovibrio bacteriovorus, a group of predatory bacteria which attack, penetrate and develop within other bacteria, came rather as a surprise. It seemed that the
Bdellovibrio bacteriovorus gen. et sp. n., a predatory, ectoparasitic, and bacteriolytic microorganism
All presently known isolates ofBdellovibrio possess lytic activity only against gram-negative bacteria; the individual strains, however, show certain differences in their host activity spectra; some have a restricted host range, while others are able to attack a broad spectrum of host bacteria.
An ATP transport system in the intracellular bacterium, Bdellovibrio bacteriovorus 109J
The intracellularly growing bacterium Bdellovibrio bacteriovorus 109J transports intact ATP by a specific, energy-requiring process. ATP transport does not involve either an ADP-ATP or an AMP-ATP
Analysis of phenotypic diversity among host-independent mutants of Bdellovibrio bacteriovorus 109J
Host-independent mutants of the obligate bacterial parasite Bdellovibrio bacteriovorus were isolated from wild-type strain 109J and exhibited widely different growth capabilities in rich medium, with biomass doubling times and final biomass varying by a factor of two or more.
Electron Microscopic Observations on the Penetration of Bdellovibrio bacteriovorus into Gram-negative Bacterial Hosts
The progressive stages in Bdellovibrio bacteriovorus penetration into two strains of Escherichia coli were examined by use of electron microscopic techniques and an attempt is made to correlate the fine structural changes involved in penetration with the physiological data that have accumulated to date.
A new model for the penetration of prey cells by bdellovibrios
A model is proposed in which it is the peptidase activity of the bdellovibrios which allows them to breach the peptIDoglycan of their prey and in which the glycanase activity exhibited by strain 109J and other bdllovibRIos is responsible for the rounding of thebdelloplast.
Type IV pili and twitching motility.
  • J. Mattick
  • Biology
    Annual review of microbiology
  • 2002
Twitching motility is a flagella-independent form of bacterial translocation over moist surfaces that is important in host colonization by a wide range of plant and animal pathogens, as well as in the formation of biofilms and fruiting bodies.
Intraperiplasmic growth of Bdellovibrio bacteriovorus 109J: solubilization of Escherichia coli peptidoglycan
During penetration of Bdellovibrio bacteriovorus into Escherchia coli, two enzymatic activities, a glycanase and a peptidase, rapidly solubilized some 10 to 15% of the E. coli peptidoglycan, which resulted in lysis of the bdelloplast and completesolubilization of the peptidglycan amino sugars and diaminopimelic acid.