A Potent Human Anti-Eotaxin1 Antibody, CAT-213: Isolation by Phage Display and in Vitro and in Vivo Efficacy

@article{Main2006APH,
  title={A Potent Human Anti-Eotaxin1 Antibody, CAT-213: Isolation by Phage Display and in Vitro and in Vivo Efficacy},
  author={Sarah H Main and Rachel L. C. Handy and Jane Wilton and Stephen Smith and Liz Williams and Leila Du Fou and John Andrews and L A Conroy and Richard D. May and Ian K. Anderson and Tristan J. Vaughan},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={319},
  pages={1395 - 1404}
}
  • S. Main, R. Handy, T. Vaughan
  • Published 1 December 2006
  • Biology
  • Journal of Pharmacology and Experimental Therapeutics
The CC chemokine, eotaxin1 (CCL11) is an important regulator of eosinophil function. A marked accumulation of eosinophils in tissues has been correlated with the up-regulation of eotaxin1 expression in several diseases. The potential therapeutic value of neutralizing the effects of eotaxin1 in inflammatory conditions (including asthma) is under investigation. A human single-chain fragment variable antibody that neutralizes human eotaxin1 (CAT-212) was produced using antibody phage display and… 
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