A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents

@inproceedings{Luo2012APC,
  title={A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents},
  author={Jian Luo and Gayathri Swaminath and Sean P Brown and Jane Tong Wen Zhang and Qi Guo and Michael Isaac Chen and Kathy Nguyen and Thanhvien Tran and Lynn Miao and Paul J. Dransfield and Marc Vimolratana and Jonathan B. Houze and Simon Wong and Maria M Toteva and Bei Shan and Frank Ning Li and Run Zhuang and Daniel C.-H. Lin},
  booktitle={PloS one},
  year={2012}
}
Type 2 diabetes is characterized by impaired glucose homeostasis due to defects in insulin secretion, insulin resistance and the incretin response. GPR40 (FFAR1 or FFA1) is a G-protein-coupled receptor (GPCR), primarily expressed in insulin-producing pancreatic β-cells and incretin-producing enteroendocrine cells of the small intestine. Several GPR40 agonists, including AMG 837 and TAK-875, have been disclosed, but no GPR40 synthetic agonists have been reported that engage both the… CONTINUE READING
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