A Potent 1,4-Dihydropyridine L-type Calcium Channel Blocker, Benidipine, Promotes Osteoblast Differentiation

@article{Nishiya2001AP1,
  title={A Potent 1,4-Dihydropyridine L-type Calcium Channel Blocker, Benidipine, Promotes Osteoblast Differentiation},
  author={Yumi Nishiya and Nobuo Kosaka and Masako Uchii and Shigeo Sugimoto},
  journal={Calcified Tissue International},
  year={2001},
  volume={70},
  pages={30-39}
}
During their differentiation, osteoblasts sequentially express type I collagen, alkaline phosphatase (ALP), and osteocalcin, and then undergo mineral deposition. Among dihydropyridine-type calcium channel blockers, only benidipine stimulated ALP activity of osteoblastic cells derived from neonatal mouse calvaria. To identify the molecular target of benidipine and elucidate the mechanism of action of the drug in osteoblasts, the mouse osteoblastic cell line MC3T3-E1 was used. Benidipine prompted… Expand
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