A Potent, Versatile Disulfide-Reducing Agent from Aspartic Acid

Abstract

Dithiothreitol (DTT) is the standard reagent for reducing disulfide bonds between and within biological molecules. At neutral pH, however, >99% of DTT thiol groups are protonated and thus unreactive. Herein, we report on (2S)-2-amino-1,4-dimercaptobutane (dithiobutylamine or DTBA), a dithiol that can be synthesized from l-aspartic acid in a few high… (More)
DOI: 10.1021/ja211931f

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Cite this paper

@inproceedings{Lukesh2012APV, title={A Potent, Versatile Disulfide-Reducing Agent from Aspartic Acid}, author={John C. Lukesh and Michael J. Palte and Ronald T. Raines}, booktitle={Journal of the American Chemical Society}, year={2012} }