A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation

@article{Suda2008APM,
  title={A Postpartum Model in Rat: Behavioral and Gene Expression Changes Induced by Ovarian Steroid Deprivation},
  author={Seiichi Suda and Eri Segi-Nishida and Samuel Sathyanesan Newton and Ronald S Duman},
  journal={Biological Psychiatry},
  year={2008},
  volume={64},
  pages={311-319}
}
BACKGROUND Postpartum depression (PPD) affects approximately 10% to 20% of women during the first 4 weeks of the postpartum period and is characterized by labile mood with prominent anxiety and irritability, insomnia, and depressive mood. During the postpartum period, elevated ovarian hormones abruptly decrease to the early follicular phase levels that are postulated to play a major role in triggering PPD. However, the underlying neurobiological mechanisms that contribute to PPD have not been… CONTINUE READING

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