A Post-Trial Assessment of Factors Influencing Study Drug Adherence in a Randomized Biomedical HIV-1 Prevention Trial

@article{Jacob2010APA,
  title={A Post-Trial Assessment of Factors Influencing Study Drug Adherence in a Randomized Biomedical HIV-1 Prevention Trial},
  author={Shevin T. Jacob and Jared M Baeten and James P. Hughes and Jes{\'u}s Peinado and Jing Wang and Jorge S{\'a}nchez and Stewart E Reid and Sinead A Delany-Moretlwe and Frances M Cowan and Jonathan D. Fuchs and Beryl A Koblin and Sam Griffith and Anna Wald and Connie L Celum},
  journal={AIDS and Behavior},
  year={2010},
  volume={15},
  pages={897-904}
}
High adherence and maintenance of blinding are critical for placebo-controlled efficacy trials of HIV-1 biomedical prevention strategies. We assessed adherence to study drug and factors affecting adherence, including perceived randomization group, in a post-trial questionnaire of participants who completed HPTN 039, a randomized, placebo-controlled trial of HSV-2 suppression with twice-daily acyclovir to reduce HIV-1 acquisition. Of the 3172 trial participants, 2003 (63%) completed the post… CONTINUE READING
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