A Possible Role for Idiotype/Anti-idiotype B–T Cell Interactions in Maintaining Immune Memory

Abstract

Variable regions of both B-cell receptors (BCRs) and T-cell receptors (TCRs) are completely formed in the postnatal period, and, consequently, no innate immune tolerance against these structures exists in adulthood. Indeed, antibodies (Abs) specific to TCRs have been found in both animals and humans. These facts clearly indicate the existence of B cells… (More)
DOI: 10.3389/fimmu.2017.00409

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