A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes.

@article{Maeda2008APG,
  title={A Porphyromonas gingivalis tyrosine phosphatase is a multifunctional regulator of virulence attributes.},
  author={Kazuhiko Maeda and Gena D. Tribble and Chelsea M Tucker and Cecilia Anaya and Satoshi Shizukuishi and Janina P. Lewis and Donald R Demuth and Richard J Lamont},
  journal={Molecular microbiology},
  year={2008},
  volume={69 5},
  pages={
          1153-64
        }
}
Low Molecular Weight Tyrosine Phosphatases (LMWTP) are widespread in prokaryotes; however, understanding of the signalling cascades controlled by these enzymes is still emerging. Porphyromonas gingivalis, an opportunistic oral pathogen, expresses a LMWTP, Ltp1, that is differentially regulated in biofilm communities. Here we characterize the enzymatic activity of Ltp1 and, through the use of mutants that lack Ltp1 or expresses catalytically defective Ltp1, show that tyrosine phosphatase… CONTINUE READING

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