A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine

@article{Francis2019APP,
  title={A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine},
  author={J. Francis and S. Zvada and P. Denti and M. Hatherill and S. Charalambous and S. Mungofa and R. Dawson and Susan Dorman and N. Gupte and L. Wiesner and A. Jindani and T. Harrison and A. Olagunju and D. Egan and A. Owen and H. McIlleron},
  journal={Antimicrobial Agents and Chemotherapy},
  year={2019},
  volume={63}
}
  • J. Francis, S. Zvada, +13 authors H. McIlleron
  • Published 2019
  • Medicine
  • Antimicrobial Agents and Chemotherapy
  • Rifapentine is a rifamycin used to treat tuberculosis. As is the case for rifampin, plasma exposures of rifapentine are associated with the treatment response. ABSTRACT Rifapentine is a rifamycin used to treat tuberculosis. As is the case for rifampin, plasma exposures of rifapentine are associated with the treatment response. While concomitant food intake and HIV infection explain part of the pharmacokinetic variability associated with rifapentine, few studies have evaluated the contribution… CONTINUE READING
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