A Population Genetics-Phylogenetics Approach to Inferring Natural Selection in Coding Sequences

@inproceedings{Wilson2011APG,
  title={A Population Genetics-Phylogenetics Approach to Inferring Natural Selection in Coding Sequences},
  author={Daniel J. Wilson and Ryan D. Hernandez and Peter Andolfatto and Molly Przeworski},
  booktitle={PLoS genetics},
  year={2011}
}
Through an analysis of polymorphism within and divergence between species, we can hope to learn about the distribution of selective effects of mutations in the genome, changes in the fitness landscape that occur over time, and the location of sites involved in key adaptations that distinguish modern-day species. We introduce a novel method for the analysis of variation in selection pressures within and between species, spatially along the genome and temporally between lineages. We model codon… CONTINUE READING
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The effect of linkage on limits to artificial selection

  • JB Plotkin, G Kudla
  • Genet Res
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