A Population Genetic Approach to Mapping Neurological Disorder Genes Using Deep Resequencing

@inproceedings{Myers2011APG,
  title={A Population Genetic Approach to Mapping Neurological Disorder Genes Using Deep Resequencing},
  author={Rachel A. Myers and Ferran Casals and Julie L Gauthier and Fadi Hamdan and Jon Keebler and Adam R. Boyko and Carlos Daniel Bustamante and Am{\'e}lie Piton and Dan Spiegelman and Edouard Henrion and M. Zilversmit and Julie G. Hussin and Jacklyn Quinlan and Yan Yang and Ronald G. Lafreni{\'e}re and Alexander R. Griffing and Eric A. Stone and Guy Rouleau and Philip Awadalla},
  booktitle={PLoS genetics},
  year={2011}
}
Deep resequencing of functional regions in human genomes is key to identifying potentially causal rare variants for complex disorders. Here, we present the results from a large-sample resequencing (n  =  285 patients) study of candidate genes coupled with population genetics and statistical methods to identify rare variants associated with Autism Spectrum Disorder and Schizophrenia. Three genes, MAP1A, GRIN2B, and CACNA1F, were consistently identified by different methods as having significant… CONTINUE READING
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